Imidacloprid and Moxidectin Spot-on Solutions(for Dogs) 

【Main Ingredient】

Imidacloprid, Moxidectin

【Appearance】

Yellow to brown yellow liquid.

【Pharmacologic action】

Antiparasitic drug.

Pharmacodynamics: Imidacloprid is a new generation of chlorinated nicotine insecticides. It has a high affinity for postsynaptic nicotinic acetylcholine receptors in the central nervous system of insects, and can inhibit the activity of acetylcholine, leading to parasite paralysis and death. It is effective against adult fleas and young fleas at various stages, and also has a kiling effect on young fleas in the environment. The mechanism of action of moxidectin is similar to that of abamectin and ivermectin, and it has a good kiling effect on internal and external parasites, especially nematodes and arthropods. The release of butyric acid(GABA) increases its binding force to the postsynaptic receptor,and the chloride channel opens. Moxidectin also has selectivity and high affinity for glutamate-mediated chloride ion channels, thereby interfering with neuromuscular signal transmission, relaxing and paralyzing the parasites, leading to the death of the parasites. Inhibitory interneurons and excitatory motor neurons in nematodes are its sites of action, while in arthropods it is the neuromuscular junction. The combination of the two has a synergistic effect.

Pharmacokinetics: After the first administration,imidacloprid was rapidly distributed to the dog’s body surface on the same day, and remained on the body surface during the administration interval 4-9 days after administration, the plasma concentration of moxidectin in dogs reaches the highest level, and it is distributed throughout the body within one month and is slowly metabolized and excreted.

【Indications】
For the prevention and treatment of internal and external parasitic infections in dogs. Prevention and treatment of flea infestations (Ctenocephalic canis), treatment of lice infestations (Catonicus canis), treatment of ear mite infestations(ltchy otica), canine sarcoids(Scabies mites), and demodicosis(Demodex canis), for the treatment of Angiostrongylus and gastrointestinal nematode infections (adults, immature aduts and L4 larvae of Toxocara canis, Ancylostoma canis, and Ancylocephalus larvae;adults of Toxocara lionis and Trichocephala vixensis). And can be used as an adjuvant treatment of allergic dermatitis caused by fleas.

【Usage and dosage】
Forexternal use, drop this product on the skin from the back of the dog between the two shoulder blades to the buttocks, and divide it into 3-4 places. One dose, for dogs, per 1kg of body weight, 10mg of imidacloprid and 2.5mg of moxidectin, equivalent to 0.1ml of this product. During prophylaxis ortreatment, it is recommended to administer once a month. Prevent dogs from licking.

【Side effect】

(1)In individual cases, this product may cause a local allergic reaction,causing transient itching, hair adhesion, erythema or vomiting. These symptoms disappear without treatment.

(2)After administration, if the animal licks the administration site, transient neurological symptoms may occasionally appear, such as excitement, tremor,ophthalmic symptoms(dilated pupils, pupillary reflexes, and nystagmus), abnormal breathing, salivation, and Symptoms such as vomiting; occasionally transient behavioral changes such as reluctance to exercise, excitement, and loss of appetite occur.

【Precautions】

(1)Do not use for puppies under 7 weeks of age. Dogs who are allergic to this product should not use it. Pregnant and lactating dogs should follow veterinary advice before use.

(2)Dogs under 1kg must follow veterinary advice when using this product.

(3)This product contains moxidectin(macrocyclic  lactone), so  when  using this product  on  collies,old  English sheepdogs and related breeds,special attention should be paid to prevent these dogs from licking this product by mouth.

(4)Sick dogs and dogs with weak physique should follow the advice of veterinarians when using it.

(5)This product should not be used on cats.

(6)During the use of this product,do not allow the drug in the drug tube to contact the eyes and mouth of the administered animal or other animals.Prevent animals that have run out of medicine from licking each other. Do not touch or trim the hair until the medicine is dry.

(7)Occasional 1 or 2 exposure of dogs to water during the administration period will not significantly affect the efficacy of the drug. However, frequent use of shampoo for bathing or soaking in water by dogs may    affect the efficacy of the drug.

(8)Keep children out of contact with this product.

(9)Do not store above 30℃,and do not use beyond the label expiration date.

(10)People who are allergic to this product should not administer it.

(11)When administering the drug,the user should avoid contact with the skin,eyes and mouth of this product, and do not eat,drink or smoke; after the administration, the hands should be washed. If it accidentally splashes on the skin,washit with soap and water immediately;if it accidentally splashes into the eyes,rinse it with water immediately.

(12)At present,there is no specific rescue medicine for this product;if swallowed by mistake,oral activated charcoal can help detoxification.

(13)The solvent in this product may contaminate materials such as leather,fabrics,plastics,and painted surfaces. Before the administration site is dry,prevent these materials from contacting the administration site

(14)Do not let this product enter surface water.

(15)Unused drugs and packaging materials should be disposed of in a harmless manner according to local requirements.

【Withdrawal  period】 None

【Specification】

(1)0.4ml:Imidacloprid 40mg +Moxidectin 10mg

(2)1.0ml:Imidacloprid  100mg+Moxidectin 25mg

(3)2.5ml:Imidacloprid 250mg +Moxidectin 62.5mg

(4)4.0ml:Imidacloprid 400mg+Moxidectin 100mg

 【Storage】

Sealed,stored at room temperature.

【Shelf life】

3 years